EXHAUSTION PARALYSIS.

PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis

Immune responses to persistent viral infections and cancer often fail because of intense regulation of antigen-specific T cells-a process referred to as immune exhaustion. The mechanisms that underlie the induction of exhaustion are not completely understood. To gain novel insights into this process, we simultaneously examined the dynamics of virus-specific CD8(+) and CD4(+) T cells in the livi...

SnapShot: T Cell Exhaustion

NK Cell Exhaustion

Natural killer cells are important effector lymphocytes of the innate immune system, playing critical roles in antitumor and anti-infection host defense. Tumor progression or chronic infections, however, usually leads to exhaustion of NK cells, thus limiting the antitumor/infection potential of NK cells. In many tumors or chronic infections, multiple mechanisms might contribute to the exhaustio...

Fitness without exhaustion.

stromal migration and engraftment of NOD/SCID mice. Blood. 2000;95(11):3289-3296. 5. Vagima Y, Avigdor A, Goichberg P, et al. MT1-MMP and RECK are involved in human CD34 progenitor cell retention, egress, and mobilization. J Clin Invest. 2009; 119(3):492-503. 6. Christopherson KWII, Hangoc G, Matel CR, et al. Modulation of hematopoietic stem cell homing and engraftment by CD26. Science. 2004;30...

Hyperventilation and exhaustion syndrome

Chronic stress is among the most common diagnoses in Sweden, most commonly in the form of exhaustion syndrome (ICD-10 classification - F43.8). The majority of patients with this syndrome also have disturbed breathing (hyperventilation). The aim of this study was to investigate the association between hyperventilation and exhaustion syndrome. Thirty patients with exhaustion syndrome and 14 healt...